Thank you Mr Kojima, amazing writing

    • EmmaGoldman [she/her, comrade/them]@hexbear.net
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      2 days ago

      For hair regrowth on feminizing HRT, the stack is estrogen, [antiandrogen of choice], dutasteride, topical minoxidil. Don’t use progesterone during this phase as it interacts negatively with finasteride/dutasteride and can cause hair shedding instead of regrowth, but progesterone shouldn’t be taken until Tanner stage III of breast development anyway. If you’re taking SERMs to avoid breast development, you’re not gonna want to take progesterone anyway.

      For masculinizing hrt, it’s so joever and you’re just cooked. Fuck around with the minoxidil and dutasteride all ya want, it’s basically random chance if it’ll help slow thinning or not.

      • queermunist she/her@lemmy.ml
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        1 day ago

        If you’re already on an antiandrogen, what good is a DHT blocker like dutasteride? DHT is synthesized from T, if you don’t have T you don’t have DHT.

        I am not an endoctrinologist so idk maybe I’m super wrong. 🤷‍♀️

        • EmmaGoldman [she/her, comrade/them]@hexbear.net
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          21 hours ago

          Your antiandrogen doesn’t block 100% of T and isn’t supposed to. The goal of the antiandrogen part of feminizing HRT is to reduce T levels to the typical female range. The female range is like 10-70 ng/dL where the male range is like 250-900 ng/dL.

          In fact, many common antiandrogens like spironolactone or bicalutimide don’t block production at all, they block the androgen receptors. GnRH antagonists actually block the production of sex hormones, but they’re less commonly used for HRT.

          Since your body will still have some testosterone, a DHT blocker will prevent it from being synthesized into DHT and thus can help restore miniaturized hair follicles.