Wait, migraines? Are you able to give me (what would technically legally be non-medical) information on that? Migraines run in my family and every family that comes into contact with my little brother. Aside from the botulism poisoning method, how does that work?
I get quarterly botox injections from my neurologist for my migraines. It’s 20+ little injections in my brow, jaw, neck, and shoulders. Before insurance would allow it, we had to try all other available treatments/medications, including a monthly at-home injection you give yourself. For me, at least, it’s been way better than the earlier treatments. I used to have 2-4 migraines per week at a pain around a 5 or 6 with a couple a year that would hurt more like an 8 or 9. Now I get 0-2 per week, usually no worse than a 3 on pain. It’s pretty common to go a few weeks without any, then just get one a week in the last month before my next injection.
Results vary a lot, probably because there are a lot of potential causes and even how we experience our migraines can vary so significantly. Efficacy can fade with time, too. But for me, at least, it’s held out for several years, and worked better than I or my doctor even expected.
It’s actually a labeled use nowadays. Just Google it on a burner phone (once advertised think you have migraines you’ll see nothing but migraine ads for months)
I mean a fair amount of my friends had endometriosis (not sure if that’s a geographic oddity or something worse) and now I’m curious if that could have (whole lot of hysterectomies in the gang) helped.
I mean if it would that’s just that much more infuriating…
But I’m not that knowledgeable on the difference between the impact of a cyst and the mechanism that gives cramps. My ex had endo. Miserable experience. I wish your friends the best in managing it.
Weird, my ex had endo as well… Didn’t want sex for a long time, and I was doing my best to be understanding and not pester her… Then she unexpectedly ended up in the ER with extreme pain and heavy bleeding, bad enough she was on morphine and needed a blood transfusion… It took months, but I eventually found out she had cheated on me with our son’s best friend’s dad, and that apparently triggered the event. Hence why she’s now my ex.
However, the trial ended prematurely as investigators did not meet their sample size, so the funding was discontinued.
How? Why? This kind of study should be trivially easy to complete. The medication is already on the market, generics are super cheap, administration is super simple and non-invasive and I’d guess there are plenty of women suffering from PMS. That sounds like the kind of study that a grad student could pull off on a DIY budget.
According to Google, generics are ~€0.50 per dose and they administered a single dose per patient. Let’s say placebos cost the same as the generics, then the cost for these 25 participants was less than €15.
Weirdly, they administered sildanefil vaginally. You’ll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.
The reason they cite for the decline of funding - “PMS doesn’t exist” - shows that the real reason is misogynistic managers.
Weirdly, they administered sildanefil vaginally. You’ll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.
Still something that any pharmacy can do for a low price. They only need to grind up regular sildanefil pills and put the powder into vaginal suppositories.
Our pharmacy did something similar for anal suppositories for our baby when there were covid-related shortages for ibuprofen suppositories.
Sometimes they do. Viagra was originally a heart medication that they figured out did something else.
Botox was for eye muscle disorders, now it’s used cosmetically, for migraines, and a bunch of other diseases.
Apparently 20% of drugs are prescribed off-label. It’s kind of an extension of “what do you call alternative medicine that works?”
Wait, migraines? Are you able to give me (what would technically legally be non-medical) information on that? Migraines run in my family and every family that comes into contact with my little brother. Aside from the botulism poisoning method, how does that work?
I get quarterly botox injections from my neurologist for my migraines. It’s 20+ little injections in my brow, jaw, neck, and shoulders. Before insurance would allow it, we had to try all other available treatments/medications, including a monthly at-home injection you give yourself. For me, at least, it’s been way better than the earlier treatments. I used to have 2-4 migraines per week at a pain around a 5 or 6 with a couple a year that would hurt more like an 8 or 9. Now I get 0-2 per week, usually no worse than a 3 on pain. It’s pretty common to go a few weeks without any, then just get one a week in the last month before my next injection.
Results vary a lot, probably because there are a lot of potential causes and even how we experience our migraines can vary so significantly. Efficacy can fade with time, too. But for me, at least, it’s held out for several years, and worked better than I or my doctor even expected.
It’s actually a labeled use nowadays. Just Google it on a burner phone (once advertised think you have migraines you’ll see nothing but migraine ads for months)
Viagra also alleviates PMS. Not approved for it, even though it’s prescribed for recreation to men.
I mean a fair amount of my friends had endometriosis (not sure if that’s a geographic oddity or something worse) and now I’m curious if that could have (whole lot of hysterectomies in the gang) helped.
I mean if it would that’s just that much more infuriating…
But I’m not that knowledgeable on the difference between the impact of a cyst and the mechanism that gives cramps. My ex had endo. Miserable experience. I wish your friends the best in managing it.
Weird, my ex had endo as well… Didn’t want sex for a long time, and I was doing my best to be understanding and not pester her… Then she unexpectedly ended up in the ER with extreme pain and heavy bleeding, bad enough she was on morphine and needed a blood transfusion… It took months, but I eventually found out she had cheated on me with our son’s best friend’s dad, and that apparently triggered the event. Hence why she’s now my ex.
Fuck that sucks. Relatable though.
How? Why? This kind of study should be trivially easy to complete. The medication is already on the market, generics are super cheap, administration is super simple and non-invasive and I’d guess there are plenty of women suffering from PMS. That sounds like the kind of study that a grad student could pull off on a DIY budget.
According to Google, generics are ~€0.50 per dose and they administered a single dose per patient. Let’s say placebos cost the same as the generics, then the cost for these 25 participants was less than €15.
Weirdly, they administered sildanefil vaginally. You’ll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.
The reason they cite for the decline of funding - “PMS doesn’t exist” - shows that the real reason is misogynistic managers.
Still something that any pharmacy can do for a low price. They only need to grind up regular sildanefil pills and put the powder into vaginal suppositories.
Our pharmacy did something similar for anal suppositories for our baby when there were covid-related shortages for ibuprofen suppositories.