For those into (not porny) dating sims, Date Everything very probably has both. (I have only discovered a very small part of the characters for now, so I have not verified it.) Warning though: every NPC in this game is an anthropomorphised domestic thing (objects, appliances, dust, etc).

Stardew Valley’s expansion mod Ridgeside Village instroduces a ftm character. I will not say his name for spoiler reasons, but he’s quite a touching character IMHO. (Well, although unoffical, he is a befriendable and romanceable Stardew Valley character after all.)