Seinfeld- Jerry and Elaine are exes and breify get back together at the end of season one
Friends- lots of romantic entaglements but mainly Chandler/Monica, Ross/Rachel, and Joey/Rachel
How I Met Your Mother - two of the main characters are a steady couple, the other three are a love triangle
Big Bang Theory- by the end, it’s three couples and one single guy
Any shows like these where the main characters never date each other or hook up with each other?
I want to say Resident Alien. The core 3 adult friends don’t have any romantic relations as far as I remember. Although there is one love triangle involving one of the main and side characters I guess. But the majority of the show is about real beautiful mixed-gender friendships IMO.