When you live somewhere the sun is actively trying to kill you 7+ months of the year a tinted windshield does wonders. I have one on my car and I couldn’t tell you the difference between my night vision with the tinted windshield versus untinted. If I can’t see in front of me with time to stop with the light my low beams give, I’m driving too fast.

It does nothing to stop the glare from the massive trucks with the headlights deliberately aligned to shine directly into a passenger car’s cabin. Anyone who drives at night with a tiny that dark is a danger to the public and belongs in the same camp the F350 eyemelter owners end up in for their crimes.

Oh, they’re trying to get rofecoxib back on the market in the US as an orphan drug for hemophilic arthropathy, despite celecoxib already existing and Vioxx having been pulled from the market after Bayer got caught hiding the obscene CV risk profile from the public. Once it’s available for people with joint damage from hemophilia there’s nothing (except a REMS program robust enough to keep it from coming back to market which, lol lmao) to stop it from being prescribed to anyone for anything.

All of the NSAIDs have some combination of GI, CV, and nephrotoxicity risks. Celecoxib is the least worst of them, but it still exists in the shadow of Vioxx. The conventional NSAIDs (except for naproxen and aspirin) are all associated with varying degrees of GI or CV risk and nephrotoxicity. It’s a class effect, some are worse than others, celecoxib and naproxen seem to have the best risk/benefit ratio for people who can take NSAIDs.

The 10% alcohol in this is less concerning than the absolute quantity of acetaminophen in the bottle. Acute co-ingestion of APAP and alcohol isn’t especially dangerous. Alcohol and APAP both deplete liver stores of glutathione, which one’s body uses to neutralize toxic metabolites of both substances as you mentioned. Chronic co-ingestion can cause fulminant liver failure pretty suddenly, as can acute co-ingestion of both substances in large enough quantities.

Some people are able to take what should be lethal doses of acetaminophen for prolonged periods of time with no issues, other people are uniquely susceptible to the toxic effects. The only way to find out which camp you’re in is if you end up with liver damage!

Ibuprofen has its own risks and is not nearly as benign as it’s made out to be. It won’t cause acute liver failure but taken at usual doses for long enough will give you an ulcer and utterly shred your kidneys. People who are hypocoagulable (on blood thinners/various psych meds or have an inborn or acquired bleeding disorder) shouldn’t or can’t take NSAIDs. They’re contraindicated in kidney failure, too.

All that to say the ease with which one can acquire lethal amounts of OTC painkillers in North America is a problem! If this were a saner country this wouldn’t be on the market, APAP wouldn’t be available in any combination products, and there would be quantity limits on how much you could buy at a time.

I’ve had the displeasure of almost needing a liver transplant from acetaminophen poisoning. Two weeks in the ICU in indescribable pain, then my liver decided it was fine, actually. I recovered with my factory liver intact and no sequelae but it’s not worth risking, ever.

Before the OKC bombings we used to buy chemicals to make explosives/fireworks from a catalogue and set them off in the backyard, with minimal parental supervision. The same catalog sold bulk red phosphorus and extra strength pseusoephedrine tablets were available by the hundreds at any grocery store. We never made meth but it would have been trivially easy. After OKC the fun chemicals got much harder to find and we had to content ourselves with whatever our kin smuggled in from someplace fireworks were legal.

There was a period of about 18 months where e-commerce had just begun but no one verified credit card numbers beyond ensuring that the number had the right checksum. Someone I knew found a credit card number generator on a BBS and we’d buy whatever we wanted and have it delivered to a vacant lot. Gas station receipts still had people’s entire credit card numbers printed on them, you could use those once they started verifying zip codes. None of our parents asked how a couple of barely-teenage kids were able to afford to build out custom PCs or where all the recording equipment, CDs, and books we very suddenly had came from.

The police didn’t know what the internet was. The FBI knew but didn’t understand or care about the internet. The level of surveillance we were subjected to was minimal and easily evaded as long as you kept your nose clean. It’s all relative, but compared to the panopticon we live in today it felt a lot less pervasive. If there were cameras anywhere they were so blurry it didn’t really matter.

We were a bunch of suburban delinquent shitasses but the opportunities to be a delinquent shitass have been foreclosed on in so many ways. The spaces we had to exist in, in public, no longer exist, or are heavily policed. The world seems to be in general, a lot more hostile to young people existing in public.

Everything children do today, and I’ve seen this with the kids I’ve been responsible for myself as well as more generally, is being logged somewhere. Time is much more regimented. If my kid skips class I get a text message from the school about it as soon as they’re marked tardy or absent. I see other parents monitoring their children’s location via cellphone in real time all the time. It seems absolutely suffocating. It feels suffocating as an adult having to navigate a world where everything you do is going into a database somewhere, and that’s with the memory of a time before the panopticon was so fully developed.

Are Kids Today strange or are they just doing their best to exist in a world that doesn’t have a place for them? The human experience, at its most basic, is the same as it’s always been. The conditions in which people live have changed.

Please do!

I’m down! Always looking for eastern bloc police procedurals.

The spark that begins the collapse of the American empire and a communist revolution will come from the west valley. A surprising (ha!) amount of revolutionary potential exists in the Aves.

Opana was everywhere for a few years before it got reformulated shortly after OCs. Generic oxymorphone tabs still exist but good luck finding them. Too good for this world.

Please ping me when it’s movie night!

Can I get uhhhhhhhhhhh

uhhhhhhhhhh

Can I get – you know what nevermind

I don’t think we’re actually going to recapitulate all the prior theories of illness leading up to germ theory, the reality of having the prosperity gospel guiding public health policy in the US is far worse. All this for what? What’s even going to be left to rule over? I don’t know that anyone’s even thought that far ahead, all the clear-eyed ghouls who were pulling the levers of power are gone and the slapdicks who replaced them all seem to sincerely believe the shit they’re peddling. I don’t think they understand that the infinite variety of contagious diseases we’re letting run rampant don’t care how rich you are, or how many precautions you take that you won’t let the masses have access to. Like the IRA told Margaret Thatcher: we only have to get lucky once, you have to get lucky every time. Plagues don’t discriminate. Will it fuel pogroms? Sure, but it doesn’t keep the instigators of those pogroms from dying agonizing, preventable deaths.

I don’t know if miasma theory is completely off the tables, actually. I could see libs adopting it as some kind of counterproductive attempt to triangulate some kind of public health policy while ceding material reality to the fascists, that’s their whole thing. Why organize effective resistance when you can fight battles already won and lost while chuckling at how clever you are?

We’re really going full speed ahead with the germ theory denialism, aren’t we? I look forward to the spirited debates about whether miasma theory is true or whether the oppressive smell from untreated sewage collecting everywhere is actually good for you.

It’s not even eugenics at this point, eugenicists had a coherent ideology, albeit one that needs to be destroyed. This is a reaction against the notion of public health, against the idea that social determinants of health exist, that health is anything but a consequence of an individual’s choices as a consumer and their personal virtue. Anyone who dies from an easily preventable disease deserves it for not being a rugged enough individualist.

Any intervention on a scale larger than whatever some crank on social media is selling is basically communism and must be destroyed. This is an ideology that can only take root in people who have been the benificiaries of hundreds of years of millions of people’s labor spent so they would have the privilege of not seeing infant and childhood mortality rates at pre-modern levels. It’s pro-suffering for the sake of suffering.

Eugenics is tragedy, this is farce. A humane society would put people who sincerely believe this shit to work doing disease eradication. Let them go down to the countryside and live with the people their idealism is killing.

This is already a known issue with assisted reproduction, the number of Musklets is probably into three figures by now. If he’s paying women to be surrogates somehow this makes him less unethical than most of the guys who do this.

He could also have a deal with one of the numerous unregulated sperm banks out there (for real it’s a libertarian fantasyland) to be the sole source for the $50 discount straw specials they run. If that’s the case the number could easily be into the thousands. Utterly horrifying to contemplate.

Wearily explaining, again, to a three year old that while the regimentation of time is an artifact of the development of the capitalist mode of production and the requirements of wage labor it’s still naptime and they still have to lay down