Thank you for putting everything together!

Thank you for hosting :)

Sure, but exploring astrocytes isn’t random. Astrocytes are the support/repair/maintenance cells of the CNS.

https://www.nature.com/articles/s12276-023-01148-0

If the study is reproducible, it could be a good step forward for our understanding of Alzheimer’s, even if this specific technique doesn’t translate to human astrocytes.

It’s possible that the reason we don’t have a treatment for Alzheimer’s is because a different mouse study in 2006 caused researchers to focus on the wrong physiological process.

The first author of that influential study, published in Nature in 2006, was an ascending neuroscientist: Sylvain Lesné of the University of Minnesota (UMN), Twin Cities. His work underpins a key element of the dominant yet controversial amyloid hypothesis of Alzheimer’s, which holds that Aβ clumps, known as plaques, in brain tissue are a primary cause of the devastating illness, which afflicts tens of millions globally. In what looked like a smoking gun for the theory and a lead to possible therapies, Lesné and his colleagues discovered an Aβ subtype and seemed to prove it caused dementia in rats. If Schrag’s doubts are correct, Lesné’s findings were an elaborate mirage.

A 6-month investigation by Science provided strong support for Schrag’s suspicions and raised questions about Lesné’s research. A leading independent image analyst and several top Alzheimer’s researchers—including George Perry of the University of Texas, San Antonio, and John Forsayeth of the University of California, San Francisco (UCSF)—reviewed most of Schrag’s findings at Science’s request. They concurred with his overall conclusions, which cast doubt on hundreds of images, including more than 70 in Lesné’s papers. Some look like “shockingly blatant” examples of image tampering, says Donna Wilcock, an Alzheimer’s expert at the University of Kentucky.

The authors “appeared to have composed figures by piecing together parts of photos from different experiments,” says Elisabeth Bik, a molecular biologist and well-known forensic image consultant. “The obtained experimental results might not have been the desired results, and that data might have been changed to … better fit a hypothesis.”

There is something to see, we just won’t have a treatment as fast as we would if this was in human trials.

With all the controversies around Alzheimer’s research, if this study is reproducible, it could kick start treatment in a productive direction. I’m looking at this bit in particular

Researchers noted that most existing therapies target beta-amyloid plaques, while their study focuses on astrocytes, offering a complementary strategy that could improve treatment outcomes.

As for why this is significant

https://www.alzheimers.org.uk/what-we-do/researchers/news/explaining-amyloid-research-study-controversy

It helps those that want to sell unregulated and unproven snake oil

What kind of hardware are you using on the desktop?

I can confirm that the following accounts are now banned from our instance. Some are also banned from their home instances:

• @freshprince7509@startrek.website
• @legrests@feddit.uk
• @supersumio@lemmy.today
• @0dyyy@retrolemmy.com
• @mrsharkyjr@group.lt

It’s worth a read, but if you don’t have time

What makes this revival uncomfortable is its timing. Phyllis could not respond. Her family, largely gone. There was no one left to correct the record or explain the circumstances. The image became a blank screen onto which modern viewers projected assumptions about drug use, morality, and personal failure.

Yet when her life is examined even briefly, those assumptions collapse. There is no evidence that she was a habitual drug user. No record of repeated arrests. No trail of chaos or criminality. Instead, there is a woman born into economic uncertainty, injured young, living through wartime upheaval, briefly targeted by an unjust legal system, and then settling into a quiet, unremarkable life.

The insult survives because it is easy. The truth requires effort.

The Reddit comment that circulates alongside Phyllis’s image captures something essential about her case. In 1944, freedom was conditional. It depended on fitting into social expectations, on being legible to authority, on not attracting the wrong kind of attention.

The same laws that ensnared Phyllis were used disproportionately against the poor, women, and people of colour. Their eventual repeal is often celebrated as progress, but repeal does not undo the damage done to those who lived under them.

Phyllis Stalnaker did not become a symbol in her lifetime. She did not campaign, protest, or write memoirs. Her story matters precisely because it is small. It reminds us how many lives were quietly constrained by laws that have since been forgotten, and how easily a single photograph can erase complexity.

Her revival online offers a choice. She can remain a joke, or she can be recognised as what she was: a woman shaped by her time, subjected to its injustices, and deserving of more than a label.

Thank you!

Last I checked, there wasn’t a good way to mirror playlists across different platforms. Maybe I’ll just post on here and ask if there are suggestions

I’m happy to pin a playlist if someone wants to maintain it :)

Otherwise we will probably make a playlist or two once all the nominations are in

Yeah I guess there should be rudimentary markdown to LaTeX translation programs, right?

I haven’t tried any, but I would think so yes. You can probably run a script over the files to accomplish the same thing :)

If it helps, a number of courses at my university used open source git based textbooks. For example, you can replicate this Statistics textbook using any static site generator designed for documentation: https://moderndive.com/ (https://github.com/moderndive/ModernDive_book/)

• https://rust-lang.github.io/mdBook/
• https://www.mkdocs.org/
• https://vitepress.dev/

We use vitepress for our docs: https://fedecan.ca/en/guide/get-started

Or you can get even simpler by using plain markdown files organized into folders.

In my opinion, it’s better to start off simple while writing the content since then you can pick a tool based on what type of formatting you end up needing

Oh good point 🤦

So maybe instead, we can clear all local + remote branches and tags, create a blank branch, delete main, rename the blank branch to main, then delete .git

Although the OP says that we can merge anything, and we might not have access to mess with branches

rm -rf *

git add -A
git commit -m "oops."

rm -rf .git
git init
git add .
git commit -m "bye."

git push origin main --force

Thank you

After looking through the records from our side, we have banned the following accounts: @sxybaka@lemmy.cafe @battousai@lemmy.zip @ivar@progamming.dev @wildnessreshuff@lemmy.world @gradationstwope@lemy.lol @tactsquick@sh.itjust.works @lamdelille@ttrpg.network emkata2564@futurology.today. We also flagged an additional account internally to keep an eye on moving forward.

Sorry for not being able to deal with that sooner. However, in the future please don’t engage with the accounts as you have done in this thread. It’s reasonable to leave a public comment to call them out, but it doesn’t really help anything to engage with them further than that. You also run the risk of looping in legitimate users who are not a part of the vote manipulation circle.

Hi @HikingVet@lemmy.ca, I’m going to look into the vote manipulation reports from our end. Is this the most up to date list of the accounts to look into?

The blocker runs in the main browser process rather than as a web extension, which means it isn’t subject to the limitations that extension based blockers like uBlock Origin face.

Waterfox is a fork of Firefox though, why would it face the limitations that chrome has?

You could also post this to !imadethis@lemmy.zip

The image is full screen, very innovative /s

Apparently you can also force your chosen image on other people’s devices when you call them.